| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyamine deacetylase HDAC10 |
|---|
| Ligand | BDBM50319235 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_633824 (CHEMBL1119902) |
|---|
| Ki | 40±n/a nM |
|---|
| Citation |  Wang, H; Lim, ZY; Zhou, Y; Ng, M; Lu, T; Lee, K; Sangthongpitag, K; Goh, KC; Wang, X; Wu, X; Khng, HH; Goh, SK; Ong, WC; Bonday, Z; Sun, ET Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity. Bioorg Med Chem Lett20:3314-21 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polyamine deacetylase HDAC10 |
|---|
| Name: | Polyamine deacetylase HDAC10 |
|---|
| Synonyms: | HD10 | HDA10_HUMAN | HDAC10 | Histone deacetylase | Histone deacetylase 10 | Human HDAC10 |
|---|
| Type: | Chromatin regulator; hydrolase; repressor |
|---|
| Mol. Mass.: | 71431.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q969S8 |
|---|
| Residue: | 669 |
|---|
| Sequence: | MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV
LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
LQCHPHLVA
|
|
|
|---|
| BDBM50319235 |
|---|
| n/a |
|---|
| Name | BDBM50319235 |
|---|
| Synonyms: | 6-(3-Benzoyl-ureido)-hexanoic acid hydroxyamide | CHEMBL1083439 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H19N3O4 |
|---|
| Mol. Mass. | 293.3184 |
|---|
| SMILES | ONC(=O)CCCCCNC(=O)NC(=O)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
