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TargetHistone deacetylase 11
LigandBDBM50319209
Substrate/Competitorn/a
Meas. Tech.ChEMBL_633825
Ki 9±n/a nM
Citation Wang HLim ZYZhou YNg MLu TLee KSangthongpitag KGoh KCWang XWu XKhng HHGoh SKOng WCBonday ZSun ET Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity. Bioorg Med Chem Lett 20:3314-21 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase 11
Name:Histone deacetylase 11
Synonyms:HD11 | Human HDAC11
Type:Chromatin regulator; hydrolase; repressor
Mol. Mass.:39187.66
Organism:Homo sapiens (Human)
Description:Recombinant HDAC11 was expressed in Sf9 cells.
Residue:347
Sequence:
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
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  Blast E-value cutoff:
BDBM50319209
n/a
NameBDBM50319209
Synonyms:6-[3-(4-Bromo-benzoyl)-ureido]-hexanoic acid hydroxyamide | CHEMBL1083086
TypeSmall organic molecule
Emp. Form.C14H18BrN3O4
Mol. Mass.372.214
SMILESONC(=O)CCCCCNC(=O)NC(=O)c1ccc(Br)cc1
Structure
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