| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 1 |
|---|
| Ligand | BDBM50319226 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_633815 (CHEMBL1119893) |
|---|
| IC50 | 20±n/a nM |
|---|
| Citation |  Wang, H; Lim, ZY; Zhou, Y; Ng, M; Lu, T; Lee, K; Sangthongpitag, K; Goh, KC; Wang, X; Wu, X; Khng, HH; Goh, SK; Ong, WC; Bonday, Z; Sun, ET Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity. Bioorg Med Chem Lett20:3314-21 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 1 |
|---|
| Name: | Histone deacetylase 1 |
|---|
| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55090.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13547 |
|---|
| Residue: | 482 |
|---|
| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
|
|
|
|---|
| BDBM50319226 |
|---|
| n/a |
|---|
| Name | BDBM50319226 |
|---|
| Synonyms: | 6-{3-[4-(2-Diethylamino-ethylamino)-3-nitro-benzoyl]-ureido}-hexanoic acid hydroxyamide | CHEMBL1084343 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H32N6O6 |
|---|
| Mol. Mass. | 452.5047 |
|---|
| SMILES | CCN(CC)CCNc1ccc(cc1[N+]([O-])=O)C(=O)NC(=O)NCCCCCC(=O)NO |
|---|
| Structure | 
|
|---|
Search and Browse
