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TargetHydroxycarboxylic acid receptor 2
LigandBDBM50319241
Substrate/Competitorn/a
Meas. Tech.ChEMBL_633873
IC50 5±n/a nM
Citation Ding FXShen HCWilsie LCKrsmanovic MLTaggart AKRen NCai TQWang JTong XHolt TGChen QWaters MGHammond MLTata JRColletti SL Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A. Bioorg Med Chem Lett 20:3372-5 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hydroxycarboxylic acid receptor 2
Name:Hydroxycarboxylic acid receptor 2
Synonyms:G-protein coupled receptor 109A | G-protein coupled receptor HM74A | Hydroxycarboxylic acid receptor 2 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41868.22
Organism:Homo sapiens (Human)
Description:Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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  Blast E-value cutoff:
BDBM50319241
n/a
NameBDBM50319241
Synonyms:5-(3,5-difluorophenyl)-2-(3-(1-(5-hydroxypyridin-2-yl)-1H-pyrazol-3-yl)-2-methylpropanamido)cyclohex-1-enecarboxylicacid | CHEMBL1085616
TypeSmall organic molecule
Emp. Form.C25H24F2N4O4
Mol. Mass.482.4793
SMILESCC(Cc1ccn(n1)-c1ccc(O)cn1)C(=O)NC1=C(CC(CC1)c1cc(F)cc(F)c1)C(O)=O |t:20|
Structure
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