Reaction Details |
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Target | Hydroxycarboxylic acid receptor 2 |
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Ligand | BDBM50319258 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_633873 (CHEMBL1120319) |
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IC50 | 9±n/a nM |
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Citation | Ding, FX; Shen, HC; Wilsie, LC; Krsmanovic, ML; Taggart, AK; Ren, N; Cai, TQ; Wang, J; Tong, X; Holt, TG; Chen, Q; Waters, MG; Hammond, ML; Tata, JR; Colletti, SL Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A. Bioorg Med Chem Lett20:3372-5 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hydroxycarboxylic acid receptor 2 |
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Name: | Hydroxycarboxylic acid receptor 2 |
Synonyms: | G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 41868.22 |
Organism: | Homo sapiens (Human) |
Description: | Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay. |
Residue: | 363 |
Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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BDBM50319258 |
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n/a |
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Name | BDBM50319258 |
Synonyms: | 2-(3-(1-(5-hydroxypyridin-2-yl)-1H-pyrazol-3-yl)-2-methylpropanamido)-4-propylcyclohex-1-enecarboxylicacid | CHEMBL1082823 |
Type | Small organic molecule |
Emp. Form. | C22H28N4O4 |
Mol. Mass. | 412.4821 |
SMILES | CCCC1CCC(C(O)=O)=C(C1)NC(=O)C(C)Cc1ccn(n1)-c1ccc(O)cn1 |c:9| |
Structure |
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