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TargetHistamine H4 receptor
LigandBDBM50319292
Substrate/Competitorn/a
Meas. Tech.ChEMBL_634016
Ki 971±n/a nM
Citation Savall BMEdwards JPVenable JDBuzard DJThurmond RHack MMcGovern P Agonist/antagonist modulation in a series of 2-aryl benzimidazole H4 receptor ligands. Bioorg Med Chem Lett 20:3367-71 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H4 receptor
Name:Histamine H4 receptor
Synonyms:AXOR35 | G-protein coupled receptor 105 | GPRv53 | HH4R | HISTAMINE H4 | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44517.02
Organism:Homo sapiens (Human)
Description:Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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BDBM50319292
n/a
NameBDBM50319292
Synonyms:(+/-)-5-fluoro-4-methyl-2-(2-methyl-4-(3-(6-methyl-3,6-diazabicyclo[3.2.0]heptan-3-yl)propoxy)phenyl)-1H-benzo[d]imidazole | CHEMBL1085804
TypeSmall organic molecule
Emp. Form.C24H29FN4O
Mol. Mass.408.5117
SMILESCN1CC2CN(CCCOc3ccc(-c4nc5ccc(F)c(C)c5[nH]4)c(C)c3)CC12
Structure
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