Reaction Details |
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Target | Prostaglandin D2 receptor 2 |
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Ligand | BDBM50319477 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_634231 (CHEMBL1120178) |
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Ki | 430±n/a nM |
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Citation | Tumey, LN; Robarge, MJ; Gleason, E; Song, J; Murphy, SM; Ekema, G; Doucette, C; Hanniford, D; Palmer, M; Pawlowski, G; Danzig, J; Loftus, M; Hunady, K; Sherf, B; Mays, RW; Stricker-Krongrad, A; Brunden, KR; Bennani, YL; Harrington, JJ 3-Indolyl sultams as selective CRTh2 antagonists. Bioorg Med Chem Lett20:3287-90 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin D2 receptor 2 |
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Name: | Prostaglandin D2 receptor 2 |
Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) |
Type: | Enzyme |
Mol. Mass.: | 43295.45 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y5Y4 |
Residue: | 395 |
Sequence: | MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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BDBM50319477 |
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n/a |
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Name | BDBM50319477 |
Synonyms: | CHEMBL1086341 | rac-[3-(1,1-Dioxo-2,3-dihydro-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-5-fluoro-2-methyl-indol-1-yl]-acetic acid |
Type | Small organic molecule |
Emp. Form. | C18H15FN2O4S |
Mol. Mass. | 374.386 |
SMILES | Cc1c(C2NS(=O)(=O)c3ccccc23)c2cc(F)ccc2n1CC(O)=O |
Structure |
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