| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin D2 receptor 2 |
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| Ligand | BDBM50319488 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_634231 (CHEMBL1120178) |
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| Ki | 8±n/a nM |
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| Citation |  Tumey, LN; Robarge, MJ; Gleason, E; Song, J; Murphy, SM; Ekema, G; Doucette, C; Hanniford, D; Palmer, M; Pawlowski, G; Danzig, J; Loftus, M; Hunady, K; Sherf, B; Mays, RW; Stricker-Krongrad, A; Brunden, KR; Bennani, YL; Harrington, JJ 3-Indolyl sultams as selective CRTh2 antagonists. Bioorg Med Chem Lett20:3287-90 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin D2 receptor 2 |
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| Name: | Prostaglandin D2 receptor 2 |
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| Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 43295.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5Y4 |
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| Residue: | 395 |
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| Sequence: | MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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| BDBM50319488 |
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| n/a |
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| Name | BDBM50319488 |
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| Synonyms: | CHEMBL1084901 | rac-{5-Chloro-3-[2-(3,5-dimethyl-isoxazol-4-ylmethyl)-1,1-dioxo-2,3-dihydro-1H-1lambda*6*-benzo[d]isothiazol-3-yl]-2-methyl-indol-1-yl}-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22ClN3O5S |
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| Mol. Mass. | 499.967 |
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| SMILES | Cc1noc(C)c1CN1C(c2ccccc2S1(=O)=O)c1c(C)n(CC(O)=O)c2ccc(Cl)cc12 |
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| Structure | 
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