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TargetG protein-coupled receptor 44
LigandBDBM50319495
Substrate/Competitorn/a
Meas. Tech.ChEMBL_634231
Ki 23±n/a nM
Citation Tumey LNRobarge MJGleason ESong JMurphy SMEkema GDoucette CHanniford DPalmer MPawlowski GDanzig JLoftus MHunady KSherf BMays RWStricker-Krongrad ABrunden KRBennani YLHarrington JJ 3-Indolyl sultams as selective CRTh2 antagonists. Bioorg Med Chem Lett 20:3287-90 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
G protein-coupled receptor 44
Name:G protein-coupled receptor 44
Synonyms:CD_antigen=CD294 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | G-protein coupled receptor 44 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:Enzyme
Mol. Mass.:43295.45
Organism:Homo sapiens (Human)
Description:Q9Y5Y4
Residue:395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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  Blast E-value cutoff:
BDBM50319495
n/a
NameBDBM50319495
Synonyms:CHEMBL1082610 | rac-{3-[2-(3,5-Dimethyl-isoxazol-4-ylmethyl)-1,1-dioxo-1lambda*6*-isothiazolidin-3-yl]-2-methyl-indol-1-yl}-acetic acid
TypeSmall organic molecule
Emp. Form.C20H23N3O5S
Mol. Mass.417.479
SMILESCc1noc(C)c1CN1C(CCS1(=O)=O)c1c(C)n(CC(O)=O)c2ccccc12
Structure
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