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TargetAurora kinase A
LigandBDBM50319570
Substrate/Competitorn/a
Meas. Tech.ChEMBL_634309 (CHEMBL1120722)
IC50 534±n/a nM
Citation Cheng, AC; Eksterowicz, J; Geuns-Meyer, S; Sun, Y Analysis of kinase inhibitor selectivity using a thermodynamics-based partition index. J Med Chem53:4502-10 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aurora kinase A
Name:Aurora kinase A
Synonyms:AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:Serine/threonine-protein kinase
Mol. Mass.:45830.98
Organism:Homo sapiens (Human)
Description:O14965
Residue:403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50319570
n/a
NameBDBM50319570
Synonyms:1-ethyl-3-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)urea | CHEMBL1084634
TypeSmall organic molecule
Emp. Form.C23H22N6O2
Mol. Mass.414.4598
SMILESCCNC(=O)Nc1ccc(Oc2ncccc2-c2ccnc(NC)n2)c2ccccc12
Structure
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