Reaction Details |
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Target | Cyclin-dependent kinase 1 |
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Ligand | BDBM8066 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_634454 (CHEMBL1119480) |
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Ki | 2520±n/a nM |
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Citation | Wang, S; Midgley, CA; Scaërou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors. J Med Chem53:4367-78 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 1 |
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Name: | Cyclin-dependent kinase 1 |
Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 34101.08 |
Organism: | Homo sapiens (Human) |
Description: | P06493 |
Residue: | 297 |
Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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BDBM8066 |
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n/a |
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Name | BDBM8066 |
Synonyms: | 2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1-N-dimethylbenzene-1,4-diamine, 3 | 4-N-[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1-N-dimethylbenzene-1,4-diamine | N-[4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-yl]N,N-dimethylbenzene-1,4-diamine |
Type | Small organic molecule |
Emp. Form. | C17H19N5S |
Mol. Mass. | 325.431 |
SMILES | CN(C)c1ccc(Nc2nccc(n2)-c2sc(C)nc2C)cc1 |
Structure |
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