| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 9 |
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| Ligand | BDBM50319618 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_634458 (CHEMBL1119484) |
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| Ki | 2605±n/a nM |
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| Citation |  Wang, S; Midgley, CA; Scaërou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors. J Med Chem53:4367-78 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 9 |
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| Name: | Cyclin-dependent kinase 9 |
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| Synonyms: | C-2K | CDC2L4 | CDK9 | CDK9_HUMAN | Cell division cycle 2-like protein kinase 4 | Cell division protein kinase 9 | Cyclin-Dependent Kinase 9 (CDK9) | Cyclin-dependent kinase 9 (CDK9) | Serine/threonine-protein kinase PITALRE | TAK | Tat-associated kinase complex catalytic subunit |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 42789.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 372 |
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| Sequence: | MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP
ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK
FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS
QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL
ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP
AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNP
ATTNQTEFERVF
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| BDBM50319618 |
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| n/a |
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| Name | BDBM50319618 |
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| Synonyms: | CHEMBL1084629 | N,4-Dimethyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22N6OS |
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| Mol. Mass. | 382.483 |
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| SMILES | CNc1nc(C)c(s1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1 |
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| Structure | 
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