| Reaction Details |
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 | Report a problem with these data |
| Target | Myotonin-protein kinase |
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| Ligand | BDBM50319634 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_634590 (CHEMBL1117931) |
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| IC50 | >8000±n/a nM |
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| Citation |  Wu, F; Büttner, FH; Chen, R; Hickey, E; Jakes, S; Kaplita, P; Kashem, MA; Kerr, S; Kugler, S; Paw, Z; Prokopowicz, A; Shih, CK; Snow, R; Young, E; Cywin, CL Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account. Bioorg Med Chem Lett20:3235-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Myotonin-protein kinase |
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| Name: | Myotonin-protein kinase |
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| Synonyms: | DM1PK | DMPK | DMPK_HUMAN | MDPK |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 69359.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_47059024 |
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| Residue: | 629 |
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| Sequence: | MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR
LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER
DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV
MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP
EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP
LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG
ATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTP
MELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVL
TRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPS
PRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLLFAVVLSR
AAALGCIGLVAHAGQLTAVWRRPGAARAP
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| BDBM50319634 |
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| n/a |
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| Name | BDBM50319634 |
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| Synonyms: | CHEMBL1084892 | N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-(methylamino)-2-phenylacetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16ClN3O2 |
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| Mol. Mass. | 341.792 |
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| SMILES | CNC(C(=O)Nc1cc2cc[nH]c(=O)c2cc1Cl)c1ccccc1 |
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| Structure | 
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