Reaction Details |
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Target | Myotonin-protein kinase |
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Ligand | BDBM14027 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_634590 (CHEMBL1117931) |
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IC50 | >8000±n/a nM |
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Citation | Wu, F; Büttner, FH; Chen, R; Hickey, E; Jakes, S; Kaplita, P; Kashem, MA; Kerr, S; Kugler, S; Paw, Z; Prokopowicz, A; Shih, CK; Snow, R; Young, E; Cywin, CL Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account. Bioorg Med Chem Lett20:3235-9 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Myotonin-protein kinase |
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Name: | Myotonin-protein kinase |
Synonyms: | DM1PK | DMPK | DMPK_HUMAN | MDPK |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 69359.66 |
Organism: | Homo sapiens (Human) |
Description: | gi_47059024 |
Residue: | 629 |
Sequence: | MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR
LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER
DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV
MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP
EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP
LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG
ATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTP
MELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVL
TRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPS
PRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLLFAVVLSR
AAALGCIGLVAHAGQLTAVWRRPGAARAP
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BDBM14027 |
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n/a |
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Name | BDBM14027 |
Synonyms: | 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4-diazepane-1-sulfonyl)isoquinoline | AT877 | CHEMBL38380 | CHEMBL541388 | Fasudil (HA-1077) | HA-1077 | US9687483, Fasudil | cid_163751 |
Type | Small organic molecule |
Emp. Form. | C14H17N3O2S |
Mol. Mass. | 291.369 |
SMILES | O=S(=O)(N1CCCNCC1)c1cccc2cnccc12 |
Structure |
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