Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Myotonin-protein kinase | ||
| Ligand | BDBM14029 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_634590 (CHEMBL1117931) | ||
| IC50 | >8000±n/a nM | ||
| Citation |  Wu, F; Büttner, FH; Chen, R; Hickey, E; Jakes, S; Kaplita, P; Kashem, MA; Kerr, S; Kugler, S; Paw, Z; Prokopowicz, A; Shih, CK; Snow, R; Young, E; Cywin, CL Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account. Bioorg Med Chem Lett20:3235-9 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Myotonin-protein kinase | |||
| Name: | Myotonin-protein kinase | ||
| Synonyms: | DM1PK | DMPK | DMPK_HUMAN | MDPK | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 69359.66 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | gi_47059024 | ||
| Residue: | 629 | ||
| Sequence: |
| ||
| BDBM14029 | |||
| n/a | |||
| Name | BDBM14029 | ||
| Synonyms: | (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE | 4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-1-carboxamide | US10183931, Y-27632 | Y-27632 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C14H21N3O | ||
| Mol. Mass. | 247.336 | ||
| SMILES | [H][C@@]1(CC[C@@]([H])(CC1)C(=O)Nc1ccncc1)[C@@H](C)N |r,wU:4.4,1.18,17.20,wD:4.8,1.0,(1.92,.41,;1.06,-.86,;-.27,-1.63,;-1.61,-.86,;-1.61,.68,;-1.61,2.22,;-.27,1.45,;1.06,.68,;-2.94,1.45,;-2.94,2.99,;-4.27,.68,;-5.61,1.45,;-5.61,2.99,;-6.94,3.76,;-8.28,2.99,;-8.28,1.45,;-6.94,.68,;2.6,-.86,;3.37,.47,;3.37,-2.2,)| | ||
| Structure | 
| ||