Reaction Details | |||
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Target | Cell division control protein 42 homolog | ||
Ligand | BDBM14029 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_634591 (CHEMBL1117932) | ||
IC50 | >8000±n/a nM | ||
Citation | Wu, F; Büttner, FH; Chen, R; Hickey, E; Jakes, S; Kaplita, P; Kashem, MA; Kerr, S; Kugler, S; Paw, Z; Prokopowicz, A; Shih, CK; Snow, R; Young, E; Cywin, CL Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account. Bioorg Med Chem Lett20:3235-9 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Cell division control protein 42 homolog | |||
Name: | Cell division control protein 42 homolog | ||
Synonyms: | CDC42 | CDC42_HUMAN | Cell division control protein 42 homolog | G25K GTP-binding protein | cell division cycle 42 (GTP binding protein, 25kDa) | ||
Type: | PROTEIN | ||
Mol. Mass.: | 21258.36 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_652970 | ||
Residue: | 191 | ||
Sequence: |
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BDBM14029 | |||
n/a | |||
Name | BDBM14029 | ||
Synonyms: | (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE | 4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-1-carboxamide | US10183931, Y-27632 | Y-27632 | ||
Type | Small organic molecule | ||
Emp. Form. | C14H21N3O | ||
Mol. Mass. | 247.336 | ||
SMILES | [H][C@@]1(CC[C@@]([H])(CC1)C(=O)Nc1ccncc1)[C@@H](C)N |r,wU:4.4,1.18,17.20,wD:4.8,1.0,(1.92,.41,;1.06,-.86,;-.27,-1.63,;-1.61,-.86,;-1.61,.68,;-1.61,2.22,;-.27,1.45,;1.06,.68,;-2.94,1.45,;-2.94,2.99,;-4.27,.68,;-5.61,1.45,;-5.61,2.99,;-6.94,3.76,;-8.28,2.99,;-8.28,1.45,;-6.94,.68,;2.6,-.86,;3.37,.47,;3.37,-2.2,)| | ||
Structure |