| Reaction Details |
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 | Report a problem with these data |
| Target | Cell division control protein 42 homolog |
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| Ligand | BDBM14027 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_634591 (CHEMBL1117932) |
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| IC50 | >8000±n/a nM |
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| Citation |  Wu, F; Büttner, FH; Chen, R; Hickey, E; Jakes, S; Kaplita, P; Kashem, MA; Kerr, S; Kugler, S; Paw, Z; Prokopowicz, A; Shih, CK; Snow, R; Young, E; Cywin, CL Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account. Bioorg Med Chem Lett20:3235-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cell division control protein 42 homolog |
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| Name: | Cell division control protein 42 homolog |
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| Synonyms: | CDC42 | CDC42_HUMAN | Cell division control protein 42 homolog | G25K GTP-binding protein | cell division cycle 42 (GTP binding protein, 25kDa) |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21258.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_652970 |
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| Residue: | 191 |
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| Sequence: | MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG
QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR
DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPP
EPKKSRRCVLL
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| BDBM14027 |
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| n/a |
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| Name | BDBM14027 |
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| Synonyms: | 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4-diazepane-1-sulfonyl)isoquinoline | AT877 | CHEMBL38380 | CHEMBL541388 | Fasudil (HA-1077) | HA-1077 | US9687483, Fasudil | cid_163751 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H17N3O2S |
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| Mol. Mass. | 291.369 |
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| SMILES | O=S(=O)(N1CCCNCC1)c1cccc2cnccc12 |
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| Structure | 
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