| Reaction Details |
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 | Report a problem with these data |
| Target | Cannabinoid receptor 2 |
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| Ligand | BDBM50320192 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_635413 (CHEMBL1120213) |
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| IC50 | 1300±n/a nM |
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| Citation |  Madsen-Duggan, CB; Debenham, JS; Walsh, TF; Yan, L; Huo, P; Wang, J; Tong, X; Lao, J; Fong, TM; Xiao, JC; Huang, CR; Shen, CP; Stribling, DS; Shearman, LP; Strack, AM; Goulet, MT; Hale, JJ Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett20:3750-4 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cannabinoid receptor 2 |
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| Name: | Cannabinoid receptor 2 |
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| Synonyms: | CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 39690.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34972 |
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| Residue: | 360 |
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| Sequence: | MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
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| BDBM50320192 |
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| n/a |
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| Name | BDBM50320192 |
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| Synonyms: | 6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-2H-pyrano[2,3-b]pyridin-4(3H)-one | CHEMBL1084039 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H16Cl3NO2 |
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| Mol. Mass. | 432.727 |
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| SMILES | CC1(C)CC(=O)c2cc(-c3ccc(Cl)cc3)c(nc2O1)-c1ccc(Cl)cc1Cl |
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| Structure | 
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