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TargetCannabinoid receptor 1
LigandBDBM50320199
Substrate/Competitorn/a
Meas. Tech.ChEMBL_635412
IC50 23±n/a nM
Citation Madsen-Duggan CBDebenham JSWalsh TFYan LHuo PWang JTong XLao JFong TMXiao JCHuang CRShen CPStribling DSShearman LPStrack AMGoulet MTHale JJ Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett 20:3750-4 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 1
Name:Cannabinoid receptor 1
Synonyms:CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52868.96
Organism:Homo sapiens (Human)
Description:P21554
Residue:472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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  Blast E-value cutoff:
BDBM50320199
n/a
NameBDBM50320199
Synonyms:7'-(2-chlorophenyl)-6'-(4-chlorophenyl)spiro[cyclopentane-1,2'-pyrano[2,3-b]pyridin]-4'(3'H)-one | CHEMBL1084556
TypeSmall organic molecule
Emp. Form.C24H19Cl2NO2
Mol. Mass.424.319
SMILESClc1ccc(cc1)-c1cc2C(=O)CC3(CCCC3)Oc2nc1-c1ccccc1Cl
Structure
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