| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase HCK |
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| Ligand | BDBM50320214 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_635429 (CHEMBL1120229) |
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| IC50 | 8±n/a nM |
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| Citation |  Gommermann, N; Buehlmayer, P; von Matt, A; Breitenstein, W; Masuya, K; Pirard, B; Furet, P; Cowan-Jacob, SW; Weckbecker, G New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck. Bioorg Med Chem Lett20:3628-31 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase HCK |
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| Name: | Tyrosine-protein kinase HCK |
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| Synonyms: | HCK | HCK_HUMAN | Hematopoietic cell kinase | Hemopoietic cell kinase | p59-HCK/p60-HCK | p59Hck | p61Hck |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 59600.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08631 |
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| Residue: | 526 |
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| Sequence: | MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
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| BDBM50320214 |
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| n/a |
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| Name | BDBM50320214 |
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| Synonyms: | 3-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenol | CHEMBL1083023 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24N6O |
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| Mol. Mass. | 400.4763 |
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| SMILES | CN1CCN(CC1)c1ccc(cc1)-c1cnn2c(N)c(cnc12)-c1cccc(O)c1 |
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| Structure | 
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