| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dipeptidyl peptidase 8 |
|---|
| Ligand | BDBM50320300 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_635726 (CHEMBL1120124) |
|---|
| IC50 | 23±n/a nM |
|---|
| Citation |  Cho, TP; Gang, LZ; Long, YF; Yang, W; Qian, W; Lei, Z; Jing, LJ; Ying, F; Ke, YP; Ying, L; Jun, F Synthesis and biological evaluation of bicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes. Bioorg Med Chem Lett20:3521-5 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dipeptidyl peptidase 8 |
|---|
| Name: | Dipeptidyl peptidase 8 |
|---|
| Synonyms: | DPP8 | DPP8_HUMAN | DPRP-1 | DPRP1 | Dipeptidyl peptidase 8 (DPP-8) | Dipeptidyl peptidase 8 (DPP8) | Dipeptidyl peptidase 8/9 | Dipeptidyl peptidase IV-related protein 1 | Dipeptidyl peptidase VIII | Dipeptidyl peptidase VIII (DDP-VIII) | Prolyl dipeptidase DPP8 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 103342.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q6V1X1 |
|---|
| Residue: | 898 |
|---|
| Sequence: | MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQ
LKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPK
TINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLF
QAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISN
IVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILR
ILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVI
DKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVM
ERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLY
KITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYF
EGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLY
KLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGK
KYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKY
KMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAP
VTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAH
TSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI
|
|
|
|---|
| BDBM50320300 |
|---|
| n/a |
|---|
| Name | BDBM50320300 |
|---|
| Synonyms: | (S)-1-(2-((2alpha,3aR,5S,6aS)-5-methoxyoctahydropentalen-2-ylamino)acetyl)pyrrolidine-2-carbonitrile hydrochloride | CHEMBL1082348 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H25N3O2 |
|---|
| Mol. Mass. | 291.3886 |
|---|
| SMILES | CO[C@@H]1C[C@@H]2C[C@H](C[C@@H]2C1)NCC(=O)N1CCC[C@H]1C#N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
