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TargetSmoothened homolog
LigandBDBM50320336
Substrate/Competitorn/a
Meas. Tech.ChEMBL_633891 (CHEMBL1120457)
IC50 2.7±n/a nM
Citation Lucas, BSAaron, WAn, SAustin, RJBrown, MChan, HChong, AHungate, RHuang, TJiang, BJohnson, MGKaizerman, JALee, GMcMinn, DLOrf, JPowers, JPRong, MToteva, MMUyeda, CWickramasinghe, DXu, GYe, QZhong, W Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists. Bioorg Med Chem Lett20:3618-22 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Smoothened homolog
Name:Smoothened homolog
Synonyms:G-protein- coupled-like receptor Smoothened (Smo) | SMO | SMOH | SMO_HUMAN | Smoothened homolog
Type:Protein
Mol. Mass.:86415.51
Organism:Homo sapiens (Human)
Description:Q99835
Residue:787
Sequence:
MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP
LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA
VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN
EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV
TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT
MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF
HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI
RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW
ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA
TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV
AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE
ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG
AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL
MDADSDF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50320336
n/a
NameBDBM50320336
Synonyms:(R)-(4-(4-(4-(hydroxymethyl)phenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone | CHEMBL1084734
TypeSmall organic molecule
Emp. Form.C27H26N4O2
Mol. Mass.438.5209
SMILESC[C@@H]1CN(CCN1c1nnc(-c2ccc(CO)cc2)c2ccccc12)C(=O)c1ccccc1 |r|
Structure
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