| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50320445 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_634119 (CHEMBL1119126) |
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| IC50 | >10000±n/a nM |
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| Citation |  Kolodziej, SA; Hockerman, SL; DeCrescenzo, GA; McDonald, JJ; Mischke, DA; Munie, GE; Fletcher, TR; Stehle, N; Swearingen, C; Becker, DP MMP-13 selective isonipecotamide alpha-sulfone hydroxamates. Bioorg Med Chem Lett20:3561-4 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50320445 |
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| n/a |
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| Name | BDBM50320445 |
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| Synonyms: | 4-(4-(4-(4-(2,3-dimethylphenyl)piperazine-1-carbonyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxy-1-(2-methoxyethyl)piperidine-4-carboxamide | CHEMBL1082319 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H47N5O6S |
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| Mol. Mass. | 641.821 |
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| SMILES | COCCN1CCC(CC1)(C(=O)NO)S(=O)(=O)c1ccc(cc1)N1CCC(CC1)C(=O)N1CCN(CC1)c1cccc(C)c1C |
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| Structure | 
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