| Reaction Details |
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 | Report a problem with these data |
| Target | KiSS-1 receptor |
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| Ligand | BDBM50320810 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_639178 (CHEMBL1167874) |
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| IC50 | 7.4±n/a nM |
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| Citation |  Kobayashi, T; Sasaki, S; Tomita, N; Fukui, S; Kuroda, N; Nakayama, M; Kiba, A; Takatsu, Y; Ohtaki, T; Itoh, F; Baba, A Synthesis and structure-activity relationships of 2-acylamino-4,6-diphenylpyridine derivatives as novel antagonists of GPR54. Bioorg Med Chem18:3841-59 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| KiSS-1 receptor |
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| Name: | KiSS-1 receptor |
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| Synonyms: | AXOR12 | G-protein Coupled Receptor 54 | G-protein coupled receptor 54 (GPR54) | GPR54 | Hypogonadotropin-1 | KISS1R | KISSR_HUMAN | KiSS-1R | Kisspeptins receptor | Metastin receptor | hOT7T175 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42613.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assay was performed using membranes from the CHO cell transfectants. |
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| Residue: | 398 |
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| Sequence: | MHTVATSGPNASWGAPANASGCPGCGANASDGPVPSPRAVDAWLVPLFFAALMLLGLVGN
SLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNY
IQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLAL
HRLSPGPRAYCSEAFPSRALERAFALYNLLALYLLPLLATCACYAAMLRHLGRVAVRPAP
ADSALQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLVLQALGPAGSWHPRSYA
AYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCPCAPRRPRRPRRPGPSDPAAPH
AELLRLGSHPAPARAQKPGSSGLAARGLCVLGEDNAPL
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| BDBM50320810 |
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| n/a |
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| Name | BDBM50320810 |
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| Synonyms: | CHEMBL1165222 | N-(4-(3-(3-aminopropanamido)phenyl)-3-cyano-6-(4-fluoro-2-hydroxyphenyl)pyridin-2-yl)thiophene-2-carboxamide | N-{4-[3-(beta-Alanylamino)phenyl]-3-cyano-6-(4-fluoro-2-hydroxyphenyl)pyridin-2-yl}thiophene-2-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C26H20FN5O3S |
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| Mol. Mass. | 501.532 |
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| SMILES | NCCC(=O)Nc1cccc(c1)-c1cc(nc(NC(=O)c2cccs2)c1C#N)-c1ccc(F)cc1O |
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| Structure | 
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