| Reaction Details |
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 | Report a problem with these data |
| Target | Falcipain 2 |
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| Ligand | BDBM50187253 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_641372 (CHEMBL1175064) |
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| Ki | 4000±n/a nM |
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| Citation |  Ettari, R; Zappalà, M; Micale, N; Schirmeister, T; Gelhaus, C; Leippe, M; Evers, A; Grasso, S Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain. Eur J Med Chem45:3228-33 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Falcipain 2 |
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| Name: | Falcipain 2 |
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| Synonyms: | Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55912.60 |
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| Organism: | Plasmodium falciparum |
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| Description: | Recombinant falcipain-2. |
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| Residue: | 484 |
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| Sequence: | MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
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| BDBM50187253 |
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| n/a |
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| Name | BDBM50187253 |
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| Synonyms: | ((3R)-1-(2-((3S)-2-hydroxy-5-oxotetrahydrofuran-3-ylamino)-2-oxoethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl 4-chloro-2-(trifluoromethyl)phenylcarbamate | ((R)-1-(2-((3S)-2-hydroxy-5-oxo-tetrahydrofuran-3-ylamino)-2-oxoethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl 4-chloro-2-(trifluoromethyl)phenylcarbamate | (4-Chloro-2-trifluoromethylphenyl)-carbamic acid 1-[(2-hydroxy-5-oxo-tetrahydrofuran-3(S)-ylcarbamoyl)-methyl]-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3(R)-ylmethyl ester | CHEMBL378223 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H24ClF3N4O7 |
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| Mol. Mass. | 644.982 |
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| SMILES | OC1OC(=O)C[C@@H]1NC(=O)CN1c2ccccc2C(=N[C@H](COC(=O)Nc2ccc(Cl)cc2C(F)(F)F)C1=O)c1ccccc1 |c:20| |
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| Structure | 
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