Reaction Details |
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Target | Falcipain 2 |
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Ligand | BDBM50321811 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_641372 (CHEMBL1175064) |
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Ki | 8200±n/a nM |
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Citation | Ettari, R; Zappalà, M; Micale, N; Schirmeister, T; Gelhaus, C; Leippe, M; Evers, A; Grasso, S Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain. Eur J Med Chem45:3228-33 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Falcipain 2 |
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Name: | Falcipain 2 |
Synonyms: | Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2 |
Type: | Enzyme |
Mol. Mass.: | 55912.60 |
Organism: | Plasmodium falciparum |
Description: | Recombinant falcipain-2. |
Residue: | 484 |
Sequence: | MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
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BDBM50321811 |
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n/a |
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Name | BDBM50321811 |
Synonyms: | (4-Chloro-2-trifluoromethyl-phenyl)-carbamic acid 1-{[(2R,3S)-2-tert-butylthio-5-oxo-tetrahydrofuran-3-ylcarbamoyl]-methyl}-(3R)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl ester | CHEMBL1171866 |
Type | Small organic molecule |
Emp. Form. | C34H32ClF3N4O6S |
Mol. Mass. | 717.154 |
SMILES | CC(C)(C)S[C@H]1OC(=O)C[C@@H]1NC(=O)CN1c2ccccc2C(=N[C@H](COC(=O)Nc2ccc(Cl)cc2C(F)(F)F)C1=O)c1ccccc1 |r,c:24| |
Structure |
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