| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cysteine protease |
|---|
| Ligand | BDBM50321812 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_641374 (CHEMBL1175066) |
|---|
| Ki | 800±n/a nM |
|---|
| Citation |  Ettari, R; Zappalà, M; Micale, N; Schirmeister, T; Gelhaus, C; Leippe, M; Evers, A; Grasso, S Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain. Eur J Med Chem45:3228-33 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cysteine protease |
|---|
| Name: | Cysteine protease |
|---|
| Synonyms: | Rhodesain |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 48425.78 |
|---|
| Organism: | Trypanosoma brucei rhodesiense |
|---|
| Description: | ChEMBL_619861 |
|---|
| Residue: | 450 |
|---|
| Sequence: | MPRTEMVRFVRLPVVLLAMAACLASVALGSLHVEESLEMRFAAFKKKYGKVYKDAKEEAF
RFRAFEENMEQAKIQAAANPYATFGVTPFSDMTREEFRARYRNGASYFAAAQKRLRKTVN
VTTGRAPAAVDWREKGAVTPVKDQGQCGSCWAFSTIGNIEGQWQVAGNPLVSLSEQMLVS
CDTIDFGCGGGLMDNAFNWIVNSNGGNVFTEASYPYVSGNGEQPQCQMNGHEIGAAITDH
VDLPQDEDAIAAYLAENGPLAIAVDATSFMDYNGGILTSCTSEQLDHGVLLVGYNDSSNP
PYWIIKNSWSNMWGEDGYIRIEKGTNQCLMNQAVSSAVVGGPTPPPPPPPPPSATFTQDF
CEGKGCTKGCSHATFPTGECVQTTGVGSVIATCGASNLTQIIYPLSRSCSGLSVPITVPL
DKCIPILIGSVEYHCSTNPPTKAARLVPHQ
|
|
|
|---|
| BDBM50321812 |
|---|
| n/a |
|---|
| Name | BDBM50321812 |
|---|
| Synonyms: | (4-Chloro-2-trifluoromethyl-phenyl)-carbamic acid 1-{[(2S,3S)-2-benzyloxy-5-oxo-tetrahydrofuran-3-ylcarbamoyl]-methyl}-(3R)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl ester | CHEMBL1171868 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C37H30ClF3N4O7 |
|---|
| Mol. Mass. | 735.105 |
|---|
| SMILES | FC(F)(F)c1cc(Cl)ccc1NC(=O)OC[C@H]1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@H]2CC(=O)O[C@@H]2OCc2ccccc2)C1=O |r,t:18| |
|---|
| Structure | 
|
|---|
Search and Browse
