Reaction Details |
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Target | Aurora kinase A |
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Ligand | BDBM50322811 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_642509 (CHEMBL1175882) |
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IC50 | 827±n/a nM |
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Citation | Coumar, MS; Chu, CY; Lin, CW; Shiao, HY; Ho, YL; Reddy, R; Lin, WH; Chen, CH; Peng, YH; Leou, JS; Lien, TW; Huang, CT; Fang, MY; Wu, SH; Wu, JS; Chittimalla, SK; Song, JS; Hsu, JT; Wu, SY; Liao, CC; Chao, YS; Hsieh, HP Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification. J Med Chem53:4980-8 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase A |
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Name: | Aurora kinase A |
Synonyms: | AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 45830.98 |
Organism: | Homo sapiens (Human) |
Description: | O14965 |
Residue: | 403 |
Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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BDBM50322811 |
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n/a |
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Name | BDBM50322811 |
Synonyms: | (2,5-Dimethoxy-2,5-dihydrofuran-2-ylmethyl)-(5,6-diphenylfuro-[2,3-d]pyrimidin-4-yl)amine | CHEMBL1173544 |
Type | Small organic molecule |
Emp. Form. | C25H23N3O4 |
Mol. Mass. | 429.4678 |
SMILES | COC1OC(CNc2ncnc3oc(c(-c4ccccc4)c23)-c2ccccc2)(OC)C=C1 |c:34| |
Structure |
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