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TargetAurora kinase A
LigandBDBM50322811
Substrate/Competitorn/a
Meas. Tech.ChEMBL_642509 (CHEMBL1175882)
IC50 827±n/a nM
Citation Coumar, MSChu, CYLin, CWShiao, HYHo, YLReddy, RLin, WHChen, CHPeng, YHLeou, JSLien, TWHuang, CTFang, MYWu, SHWu, JSChittimalla, SKSong, JSHsu, JTWu, SYLiao, CCChao, YSHsieh, HP Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification. J Med Chem53:4980-8 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aurora kinase A
Name:Aurora kinase A
Synonyms:AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:Serine/threonine-protein kinase
Mol. Mass.:45830.98
Organism:Homo sapiens (Human)
Description:O14965
Residue:403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50322811
n/a
NameBDBM50322811
Synonyms:(2,5-Dimethoxy-2,5-dihydrofuran-2-ylmethyl)-(5,6-diphenylfuro-[2,3-d]pyrimidin-4-yl)amine | CHEMBL1173544
TypeSmall organic molecule
Emp. Form.C25H23N3O4
Mol. Mass.429.4678
SMILESCOC1OC(CNc2ncnc3oc(c(-c4ccccc4)c23)-c2ccccc2)(OC)C=C1 |c:34|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: