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TargetAnandamide amidohydrolase
LigandBDBM50323048
Substrate/Competitorn/a
Meas. Tech.ChEMBL_643589
IC50 232±n/a nM
Citation Gattinoni SSimone CDDallavalle SFezza FNannei RBattista NMinetti PQuattrociocchi GCaprioli ABorsini FCabri WPenco SMerlini LMaccarrone M A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett 20:4406-11 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Anandamide amidohydrolase
Name:Anandamide amidohydrolase
Synonyms:Anandamide amidohydrolase 1 | Fatty Acid Amide Hydrolase | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:Hydrolase; single-pass membrane protein; homodimer
Mol. Mass.:63227.28
Organism:Mus musculus (mouse)
Description:Mouse brain membranes were used in the assay.
Residue:579
Sequence:
MVLSEVWTALSGLSGVCLACSLLSAAVVLRWTRSQTARGAVTRARQKQRAGLETMDKAVQ
RFRLQNPDLDSEALLALPLLQLVQKLQSGELSPEAVLFTYLGKAWEVNKGTNCVTSYLTD
CETQLSQAPRQGLLYGVPVSLKECFSYKGHASTLGLSLNEGVTSESDCVVVQVLKLQGAV
PFVHTNVPQSMLSYDCSNPLFGQTMNPWKPSKSPGGSSGGEGALIGSGGSPLGLGTDIGG
SIRFPSAFCGICGLKPTGNRLSKSGLKSCVYGQTAVQLSVGPMARDVDSLALCMKALLCE
DLFRLDSTIPPLPFREEIYRSSRPLRVGYYETDNYTMPTPAMRRAVMETKQSLEAAGHTL
VPFLPNNIPYALEVLSAGGLFSDGGCSFLQNFKGDFVDPCLGDLVLVLKLPRWFKKLLSF
LLKPLFPRLAAFLNSMCPRSAEKLWELQHEIEMYRQSVIAQWKAMNLDVVLTPMLGPALD
LNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMEHYKGYFGDMWDNILKKGMK
KGIGLPVAVQCVALPWQEELCLRFMREVERLMTPEKRPS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50323048
n/a
NameBDBM50323048
Synonyms:1-Biphenyl-3-yl-ethanone, O-[(5-benzo[b]thiophenyl)amino]carbonyl)oxime | CHEMBL1210094
TypeSmall organic molecule
Emp. Form.C23H18N2O2S
Mol. Mass.386.466
SMILESCC(=NOC(=O)Nc1ccc2sccc2c1)c1cccc(c1)-c1ccccc1 |w:2.2|
Structure
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