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TargetCytochrome P450 11B2, mitochondrial
LigandBDBM50323342
Substrate/Competitorn/a
Meas. Tech.ChEMBL_643964 (CHEMBL1211863)
IC50 2.5±n/a nM
Citation Adams, CMHu, CWJeng, AYKarki, RKsander, GLasala, DLeung-Chu, JLiang, GLiu, QMeredith, ERao, CRigel, DFShi, JSmith, SSpringer, CZhang, C The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase. Bioorg Med Chem Lett20:4324-7 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 11B2, mitochondrial
Name:Cytochrome P450 11B2, mitochondrial
Synonyms:Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase
Type:Protein
Mol. Mass.:57582.15
Organism:Homo sapiens (Human)
Description:P19099
Residue:503
Sequence:
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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  Blast E-value cutoff:
BDBM50323342
n/a
NameBDBM50323342
Synonyms:6-(4-Fluoro-benzyl)-4-isobutyl-6,7-dihydro-5-thia-2,3a,6-triaza-indene 5,5-dioxide | CHEMBL1209476
TypeSmall organic molecule
Emp. Form.C16H20FN3O2S
Mol. Mass.337.412
SMILESCC(C)CC1n2cncc2CN(Cc2ccc(F)cc2)S1(=O)=O
Structure
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