| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 2 |
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| Ligand | BDBM50323391 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_644014 (CHEMBL1211913) |
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| IC50 | 990±n/a nM |
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| Citation |  Imbriglio, JE; Chang, S; Liang, R; Raghavan, S; Schmidt, D; Smenton, A; Tria, S; Schrader, TO; Jung, JK; Esser, C; Holt, TG; Wolff, MS; Taggart, AK; Cheng, K; Carballo-Jane, E; Waters, MG; Tata, JR; Colletti, SL GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a. Bioorg Med Chem Lett20:4472-4 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 2 |
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| Name: | Hydroxycarboxylic acid receptor 2 |
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| Synonyms: | Gpr109 | Gpr109a | Gpr109b | HCAR2_MOUSE | HM74 nicotinic acid GPCR | Hcar2 | Niacr1 | Pumag |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41418.01 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_820676 |
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| Residue: | 360 |
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| Sequence: | MSKSDHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSR
IFLFNLAVADFLLIICLPFLTDNYVHNWDWRFGGIPCRVMLFMLAMNRQGSIIFLTVVAV
DRYFRVVHPHHFLNKISNRTAAIISCFLWGLTIGLTVHLLYTNMMTKNGEAYLCSSFSIC
YNFRWHDAMFLLEFFLPLAIILFCSGRIIWSLRQRQMDRHAKIKRAINFIMVVAIVFIIC
FLPSVAVRIRIFWLLYKYNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPN
FFSTCINRCLRKKTLGEPDNNRSTSVELTGDPSTTRSIPGALMADPSEPGSPPYLASTSR
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| BDBM50323391 |
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| n/a |
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| Name | BDBM50323391 |
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| Synonyms: | 5-isopropyl-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acid | CHEMBL1208920 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H14N2O2 |
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| Mol. Mass. | 194.2304 |
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| SMILES | CC(C)C1Cc2[nH]nc(C(O)=O)c2C1 |
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| Structure | 
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