Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHydroxycarboxylic acid receptor 2
LigandBDBM50273099
Substrate/Competitorn/a
Meas. Tech.ChEMBL_644015
IC50 1500±n/a nM
Citation Imbriglio JEChang SLiang RRaghavan SSchmidt DSmenton ATria SSchrader TOJung JKEsser CHolt TGWolff MSTaggart AKCheng KCarballo-Jane EWaters MGTata JRColletti SL GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a. Bioorg Med Chem Lett 20:4472-4 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hydroxycarboxylic acid receptor 2
Name:Hydroxycarboxylic acid receptor 2
Synonyms:G-protein coupled receptor 109A | G-protein coupled receptor HM74A | Hydroxycarboxylic acid receptor 2 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41868.22
Organism:Homo sapiens (Human)
Description:Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50273099
n/a
NameBDBM50273099
Synonyms:3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole | 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole | CHEMBL456145 | MK-0354
TypeSmall organic molecule
Emp. Form.C7H8N6
Mol. Mass.176.1786
SMILESC1Cc2[nH]nc(c2C1)-c1nnn[nH]1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: