Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetSmoothened homolog
LigandBDBM50323411
Substrate/Competitorn/a
Meas. Tech.ChEMBL_644050 (CHEMBL1211949)
IC50 5±n/a nM
Citation Li, JJShanmugasundaram, VReddy, SFleischer, LLWang, ZSmith, YHarter, WGYue, WSSwaroop, MLi, LJi, CXDettling, DOsak, BFitzgerald, LRConradi, R Smoothened antagonists for hair inhibition. Bioorg Med Chem Lett20:4932-5 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Smoothened homolog
Name:Smoothened homolog
Synonyms:G-protein- coupled-like receptor Smoothened (Smo) | SMO | SMOH | SMO_HUMAN | Smoothened homolog
Type:Protein
Mol. Mass.:86415.51
Organism:Homo sapiens (Human)
Description:Q99835
Residue:787
Sequence:
MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP
LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA
VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN
EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV
TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT
MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF
HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI
RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW
ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA
TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV
AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE
ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG
AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL
MDADSDF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50323411
n/a
NameBDBM50323411
Synonyms:1-((1-(4-fluorophenyl)-5-methyl-1H-pyrazol-4-yl)methyl)-4-(3-methoxyphenyl)piperazine | CHEMBL1209156
TypeSmall organic molecule
Emp. Form.C22H25FN4O
Mol. Mass.380.4585
SMILESCOc1cccc(c1)N1CCN(Cc2cnn(c2C)-c2ccc(F)cc2)CC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: