Reaction Details |
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Target | Mitogen-activated protein kinase 14 |
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Ligand | BDBM50323415 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_644072 (CHEMBL1211971) |
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IC50 | 68±n/a nM |
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Citation | Liu, H; Kuhn, C; Feru, F; Jacques, SL; Deshmukh, GD; Ye, P; Rennie, GR; Johnson, T; Kazmirski, S; Low, S; Coli, R; Ding, YH; Cheng, AC; Tecle, H; English, JM; Stanton, R; Wu, JC Enhanced selectivity profile of pyrazole-urea based DFG-out p38alpha inhibitors. Bioorg Med Chem Lett20:4885-91 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 14 |
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Name: | Mitogen-activated protein kinase 14 |
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 41286.76 |
Organism: | Homo sapiens (Human) |
Description: | Q16539 |
Residue: | 360 |
Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50323415 |
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n/a |
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Name | BDBM50323415 |
Synonyms: | CHEMBL1209273 | N-(3-(3-tert-butyl-5-(3-phenylureido)-1H-pyrazol-1-yl)benzyl)-2-formamidoacetamide |
Type | Small organic molecule |
Emp. Form. | C24H28N6O3 |
Mol. Mass. | 448.5175 |
SMILES | CC(C)(C)c1cc(NC(=O)Nc2ccccc2)n(n1)-c1cccc(CNC(=O)CNC=O)c1 |
Structure |
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