| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50323441 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_644082 (CHEMBL1211981) |
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| IC50 | 2±n/a nM |
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| Citation |  Guo, L; Ye, Z; Liu, J; He, S; Bakshi, RK; Sebhat, IK; Dobbelaar, PH; Hong, Q; Jian, T; Dellureficio, JP; Tsou, NN; Ball, RG; Weinberg, DH; MacNeil, T; Tang, R; Tamvakopoulos, C; Peng, Q; Chen, HY; Chen, AS; Martin, WJ; MacIntyre, DE; Strack, AM; Fong, TM; Wyvratt, MJ; Nargund, RP Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists. Bioorg Med Chem Lett20:4895-900 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36949.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32245 |
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| Residue: | 332 |
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| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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| BDBM50323441 |
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| n/a |
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| Name | BDBM50323441 |
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| Synonyms: | 2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile | CHEMBL1209788 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H38ClF2N3O3 |
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| Mol. Mass. | 598.123 |
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| SMILES | Cc1cc2[C@H](OC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C3CCOCC3)c2cc1Cl)C(C)(C)C#N |r| |
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| Structure | 
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