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TargetMelanocortin receptor 4
LigandBDBM50323456
Substrate/Competitorn/a
Meas. Tech.ChEMBL_644082 (CHEMBL1211981)
IC50 1±n/a nM
Citation Guo, LYe, ZLiu, JHe, SBakshi, RKSebhat, IKDobbelaar, PHHong, QJian, TDellureficio, JPTsou, NNBall, RGWeinberg, DHMacNeil, TTang, RTamvakopoulos, CPeng, QChen, HYChen, ASMartin, WJMacIntyre, DEStrack, AMFong, TMWyvratt, MJNargund, RP Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists. Bioorg Med Chem Lett20:4895-900 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 4
Name:Melanocortin receptor 4
Synonyms:MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:Enzyme
Mol. Mass.:36949.50
Organism:Homo sapiens (Human)
Description:P32245
Residue:332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50323456
n/a
NameBDBM50323456
Synonyms:(S)-(6-chloro-5-methyl-3-(2-morpholinopropan-2-yl)-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl)methanone | CHEMBL1209799
TypeSmall organic molecule
Emp. Form.C36H46ClF2N3O4
Mol. Mass.658.218
SMILESCc1cc2[C@H](OC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C3CCOCC3)c2cc1Cl)C(C)(C)N1CCOCC1 |r|
Structure
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