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TargetSubstance-K receptor
LigandBDBM21016
Substrate/Competitorn/a
Meas. Tech.ChEMBL_647568 (CHEMBL1217615)
Ki 134±n/a nM
Citation Yamamoto, TNair, PJacobsen, NEKulkarni, VDavis, PMa, SWNavratilova, EYamamura, HIVanderah, TWPorreca, FLai, JHruby, VJ Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines. J Med Chem53:5491-501 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Substance-K receptor
Name:Substance-K receptor
Synonyms:NK-2 receptor | NK-2R | NK2R_RAT | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | SKR | Substance-K receptor | Tac2r | Tachykinin receptor 2 | Tacr2
Type:Enzyme Catalytic Domain
Mol. Mass.:43868.63
Organism:Rattus norvegicus (Rat)
Description:Neurokinin NK2 TACR2 Murine::P16610
Residue:390
Sequence:
MGTRAIVSDANILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILA
HERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAIIAGIWLVALALASPQCFYSTITVDEGATK
CVVAWPNDNGGKMLLLYHLVVFVLIYFLPLLVMFGAYSVIGLTLWKRAVPRHQAHGANLR
HLQAKKKFVKAMVLVVLTFAICWLPYHLYFILGTFQEDIYYHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTHTPSLSRRVNRCHTKETLFMT
GDMTHSEATNGQVGSPQDGEPAGPICKAQA
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  Blast E-value cutoff:
BDBM21016
n/a
NameBDBM21016
Synonyms:CHEMBL22870 | L 732138 | L-732,138 | L732138 | N-acetyltryptophan 3,5-bis(trifluoromethyl)benzyl ester | [3,5-bis(trifluoromethyl)phenyl]methyl (2S)-2-acetamido-3-(1H-indol-3-yl)propanoate
TypeSmall organic molecule
Emp. Form.C22H18F6N2O3
Mol. Mass.472.3803
SMILESCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F |r|
Structure
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