| Reaction Details |
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 | Report a problem with these data |
| Target | Polycystin-2 |
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| Ligand | BDBM50324324 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_650175 (CHEMBL1219873) |
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| IC50 | 1±n/a nM |
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| Citation |  Meredith, EL; Beattie, K; Burgis, R; Capparelli, M; Chapo, J; Dipietro, L; Gamber, G; Enyedy, I; Hood, DB; Hosagrahara, V; Jewell, C; Koch, KA; Lee, W; Lemon, DD; McKinsey, TA; Miranda, K; Pagratis, N; Phan, D; Plato, C; Rao, C; Rozhitskaya, O; Soldermann, N; Springer, C; van Eis, M; Vega, RB; Yan, W; Zhu, Q; Monovich, LG Identification of potent and selective amidobipyridyl inhibitors of protein kinase D. J Med Chem53:5422-38 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Polycystin-2 |
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| Name: | Polycystin-2 |
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| Synonyms: | PKD2 | PKD2_HUMAN | TRPP2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 109676.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_886731 |
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| Residue: | 968 |
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| Sequence: | MVNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAPGGLCEQRGLEIEMQRIR
QAAARDPPAGAAASPSPPLSSCSRQAWSRDNPGFEAEEEEEEVEGEEGGMVVEMDVEWRP
GSRRSAASSAVSSVGARSRGLGGYHGAGHPSGRRRRREDQGPPCPSPVGGGDPLHRHLPL
EGQPPRVAWAERLVRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYG
MMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQ
TEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGP
RNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTR
ATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIF
CFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLE
DQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGF
AIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIY
FTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKN
TVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQMRD
DLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQ
VLVRRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEI
HREQMERLVREELERWESDDAASQISHGLGTPVGLNGQPRPRSSRPSSSQSTEGMEGAGG
NGSSNVHV
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| BDBM50324324 |
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| n/a |
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| Name | BDBM50324324 |
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| Synonyms: | 2'-Phenylamino-6-piperazin-1-yl[2,4']bipyridinyl-4-carboxylic Acid Methyl Amide | CHEMBL1215000 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22N6O |
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| Mol. Mass. | 374.439 |
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| SMILES | NC(=O)c1cc(nc(c1)-c1ccnc(Nc2ccccc2)c1)N1CCNCC1 |
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| Structure | 
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