| Reaction Details |
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 | Report a problem with these data |
| Target | Suppressor of tumorigenicity 14 protein |
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| Ligand | BDBM50324475 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_649222 (CHEMBL1218920) |
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| Ki | 55±n/a nM |
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| Citation |  Sisay, MT; Steinmetzer, T; Stirnberg, M; Maurer, E; Hammami, M; Bajorath, J; Gütschow, M Identification of the first low-molecular-weight inhibitors of matriptase-2. J Med Chem53:5523-35 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Suppressor of tumorigenicity 14 protein |
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| Name: | Suppressor of tumorigenicity 14 protein |
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| Synonyms: | Epithin | Hepatocyte growth factor activator/Serine protease hepsin/Suppressor of tumorigenicity 14 protein | MT-SP1 | Membrane-type serine protease 1 | PRSS14 | Prostamin | SNC19 | ST14 | ST14_HUMAN | Serine protease TADG-15 | Suppressor of tumorigenicity 14 protein | Suppressor of tumorigenicity protein 14 | TADG15 |
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| Type: | Single-pass type II membrane protein |
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| Mol. Mass.: | 94769.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5Y6 |
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| Residue: | 855 |
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| Sequence: | MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAA
VLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKV
KDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVM
LPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPA
HARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS
YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHY
PPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTS
NSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDH
SDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSK
SQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK
DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID
DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP
AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL
PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT
RLPLFRDWIKENTGV
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| BDBM50324475 |
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| n/a |
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| Name | BDBM50324475 |
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| Synonyms: | Benzylsulfonyl-D-argininyl-proline-(4-amidinobenzyl)amide Bis-(trifluoroacetate) | CHEMBL1215083 | CHEMBL1229259 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H36N8O4S |
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| Mol. Mass. | 556.68 |
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| SMILES | NC(=N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N |r| |
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| Structure | 
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