| Reaction Details |
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 | Report a problem with these data |
| Target | Hematopoietic prostaglandin D synthase |
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| Ligand | BDBM50324489 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_649226 (CHEMBL1218924) |
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| IC50 | 10800±n/a nM |
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| Citation |  Christ, AN; Labzin, L; Bourne, GT; Fukunishi, H; Weber, JE; Sweet, MJ; Smythe, ML; Flanagan, JU Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D(2) synthases. J Med Chem53:5536-48 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hematopoietic prostaglandin D synthase |
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| Name: | Hematopoietic prostaglandin D synthase |
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| Synonyms: | GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase |
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| Type: | Enzyme |
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| Mol. Mass.: | 23341.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag. |
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| Residue: | 199 |
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| Sequence: | MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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| BDBM50324489 |
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| n/a |
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| Name | BDBM50324489 |
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| Synonyms: | CHEMBL1215162 | N-benzhydryl-2-(3-hydroxyphenyl)thiazole-4-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C23H18N2O2S |
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| Mol. Mass. | 386.466 |
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| SMILES | Oc1cccc(c1)-c1nc(cs1)C(=O)NC(c1ccccc1)c1ccccc1 |
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| Structure | 
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