Reaction Details |
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Target | Hematopoietic prostaglandin D synthase |
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Ligand | BDBM50324491 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_649226 (CHEMBL1218924) |
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IC50 | 700±n/a nM |
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Citation | Christ, AN; Labzin, L; Bourne, GT; Fukunishi, H; Weber, JE; Sweet, MJ; Smythe, ML; Flanagan, JU Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D(2) synthases. J Med Chem53:5536-48 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hematopoietic prostaglandin D synthase |
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Name: | Hematopoietic prostaglandin D synthase |
Synonyms: | GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase |
Type: | Enzyme |
Mol. Mass.: | 23341.07 |
Organism: | Homo sapiens (Human) |
Description: | The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag. |
Residue: | 199 |
Sequence: | MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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BDBM50324491 |
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n/a |
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Name | BDBM50324491 |
Synonyms: | CHEMBL1215159 | N-Benzhydryl-5-(3-hydroxyphenyl)thiophene-2-carboxamide |
Type | Small organic molecule |
Emp. Form. | C24H19NO2S |
Mol. Mass. | 385.478 |
SMILES | Oc1cccc(c1)-c1ccc(s1)C(=O)NC(c1ccccc1)c1ccccc1 |
Structure |
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