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TargetHematopoietic prostaglandin D synthase
LigandBDBM21624
Substrate/Competitorn/a
Meas. Tech.ChEMBL_649226 (CHEMBL1218924)
IC50 1400±n/a nM
Citation Christ, ANLabzin, LBourne, GTFukunishi, HWeber, JESweet, MJSmythe, MLFlanagan, JU Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D(2) synthases. J Med Chem53:5536-48 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hematopoietic prostaglandin D synthase
Name:Hematopoietic prostaglandin D synthase
Synonyms:GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase
Type:Enzyme
Mol. Mass.:23341.07
Organism:Homo sapiens (Human)
Description:The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM21624
n/a
NameBDBM21624
Synonyms:4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid | Thiazolylamino, 12
TypeSmall organic molecule
Emp. Form.C17H13FN2O3S
Mol. Mass.344.36
SMILESCc1cc(ccc1F)-c1csc(Nc2ccc(C(O)=O)c(O)c2)n1
Structure
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