Reaction Details | |||
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Target | Dipeptidyl peptidase 8 | ||
Ligand | BDBM50324497 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_649273 (CHEMBL1218971) | ||
Ki | 1.1±n/a nM | ||
Citation | Meng, W; Brigance, RP; Chao, HJ; Fura, A; Harrity, T; Marcinkeviciene, J; O'Connor, SP; Tamura, JK; Xie, D; Zhang, Y; Klei, HE; Kish, K; Weigelt, CA; Turdi, H; Wang, A; Zahler, R; Kirby, MS; Hamann, LG Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J Med Chem53:5620-8 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Dipeptidyl peptidase 8 | |||
Name: | Dipeptidyl peptidase 8 | ||
Synonyms: | DPP8 | DPP8_HUMAN | DPRP-1 | DPRP1 | Dipeptidyl peptidase 8 (DPP-8) | Dipeptidyl peptidase 8 (DPP8) | Dipeptidyl peptidase 8/9 | Dipeptidyl peptidase IV-related protein 1 | Dipeptidyl peptidase VIII | Dipeptidyl peptidase VIII (DDP-VIII) | Prolyl dipeptidase DPP8 | ||
Type: | Enzyme | ||
Mol. Mass.: | 103342.62 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q6V1X1 | ||
Residue: | 898 | ||
Sequence: |
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BDBM50324497 | |||
n/a | |||
Name | BDBM50324497 | ||
Synonyms: | (6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)(4,4-dimethyloxazolidin-3-yl)methanone | CHEMBL1215164 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H21Cl2N5O2 | ||
Mol. Mass. | 434.319 | ||
SMILES | Cc1nc2nc(cn2c(c1CN)-c1ccc(Cl)cc1Cl)C(=O)N1COCC1(C)C |(10.72,-.55,;9.42,-1.37,;8.06,-.65,;6.76,-1.46,;5.28,-1.03,;4.42,-2.29,;5.36,-3.51,;6.81,-2.99,;8.16,-3.72,;9.46,-2.91,;10.82,-3.64,;12.13,-2.83,;8.13,-5.25,;6.78,-5.99,;6.74,-7.53,;8.07,-8.33,;8.03,-9.87,;9.42,-7.58,;9.44,-6.05,;10.79,-5.3,;2.88,-2.34,;2.07,-1.03,;2.15,-3.7,;2.66,-5.14,;1.44,-6.08,;.17,-5.2,;.61,-3.72,;-.99,-3.83,;-.16,-2.39,)| | ||
Structure |