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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dipeptidyl peptidase 8 | ||
| Ligand | BDBM50324499 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_649273 (CHEMBL1218971) | ||
| Ki | 1.7±n/a nM | ||
| Citation |  Meng, W; Brigance, RP; Chao, HJ; Fura, A; Harrity, T; Marcinkeviciene, J; O'Connor, SP; Tamura, JK; Xie, D; Zhang, Y; Klei, HE; Kish, K; Weigelt, CA; Turdi, H; Wang, A; Zahler, R; Kirby, MS; Hamann, LG Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J Med Chem53:5620-8 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dipeptidyl peptidase 8 | |||
| Name: | Dipeptidyl peptidase 8 | ||
| Synonyms: | DPP8 | DPP8_HUMAN | DPRP-1 | DPRP1 | Dipeptidyl peptidase 8 (DPP-8) | Dipeptidyl peptidase 8 (DPP8) | Dipeptidyl peptidase 8/9 | Dipeptidyl peptidase IV-related protein 1 | Dipeptidyl peptidase VIII | Dipeptidyl peptidase VIII (DDP-VIII) | Prolyl dipeptidase DPP8 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 103342.62 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q6V1X1 | ||
| Residue: | 898 | ||
| Sequence: |
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| BDBM50324499 | |||
| n/a | |||
| Name | BDBM50324499 | ||
| Synonyms: | 6-(aminomethyl)-5-(2,4-dichlorophenyl)-N-(isoxazol-3-yl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamide | CHEMBL1215166 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H14Cl2N6O2 | ||
| Mol. Mass. | 417.249 | ||
| SMILES | Cc1nc2nc(cn2c(c1CN)-c1ccc(Cl)cc1Cl)C(=O)Nc1ccon1 |(8.64,-1.31,;7.33,-2.13,;5.97,-1.41,;4.67,-2.22,;3.2,-1.79,;2.33,-3.06,;3.27,-4.28,;4.72,-3.76,;6.07,-4.49,;7.38,-3.68,;8.74,-4.4,;10.04,-3.59,;6.04,-6.02,;4.69,-6.76,;4.66,-8.3,;5.98,-9.1,;6.01,-10.69,;7.33,-8.34,;7.36,-6.81,;8.7,-6.06,;.79,-3.1,;-.02,-1.8,;.06,-4.46,;-1.48,-4.51,;-2.34,-5.78,;-3.82,-5.34,;-3.86,-3.8,;-2.42,-3.29,)| | ||
| Structure | 
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