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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dipeptidyl peptidase 8 | ||
| Ligand | BDBM50324503 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_649273 (CHEMBL1218971) | ||
| Ki | 2.5±n/a nM | ||
| Citation |  Meng, W; Brigance, RP; Chao, HJ; Fura, A; Harrity, T; Marcinkeviciene, J; O'Connor, SP; Tamura, JK; Xie, D; Zhang, Y; Klei, HE; Kish, K; Weigelt, CA; Turdi, H; Wang, A; Zahler, R; Kirby, MS; Hamann, LG Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J Med Chem53:5620-8 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dipeptidyl peptidase 8 | |||
| Name: | Dipeptidyl peptidase 8 | ||
| Synonyms: | DPP8 | DPP8_HUMAN | DPRP-1 | DPRP1 | Dipeptidyl peptidase 8 (DPP-8) | Dipeptidyl peptidase 8 (DPP8) | Dipeptidyl peptidase 8/9 | Dipeptidyl peptidase IV-related protein 1 | Dipeptidyl peptidase VIII | Dipeptidyl peptidase VIII (DDP-VIII) | Prolyl dipeptidase DPP8 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 103342.62 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q6V1X1 | ||
| Residue: | 898 | ||
| Sequence: |
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| BDBM50324503 | |||
| n/a | |||
| Name | BDBM50324503 | ||
| Synonyms: | 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methyl-N-(thiophen-2-ylmethyl)imidazo[1,2-a]pyrimidine-2-carboxamide | CHEMBL1215235 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H17Cl2N5OS | ||
| Mol. Mass. | 446.353 | ||
| SMILES | Cc1nc2nc(cn2c(c1CN)-c1ccc(Cl)cc1Cl)C(=O)NCc1cccs1 |(7.53,-1.38,;6.23,-2.19,;4.87,-1.48,;3.57,-2.29,;2.09,-1.85,;1.23,-3.12,;2.17,-4.34,;3.62,-3.82,;4.97,-4.55,;6.27,-3.74,;7.64,-4.46,;8.94,-3.65,;4.94,-6.08,;3.58,-6.82,;3.55,-8.36,;4.88,-9.16,;4.84,-10.7,;6.23,-8.41,;6.25,-6.87,;7.6,-6.13,;-.32,-3.16,;-1.13,-1.86,;-1.04,-4.53,;-2.58,-4.57,;-3.39,-3.26,;-4.93,-3.29,;-5.44,-1.83,;-4.21,-.9,;-2.95,-1.78,)| | ||
| Structure | 
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