Reaction Details | |||
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Target | Dipeptidyl peptidase 8 | ||
Ligand | BDBM50324517 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_649273 (CHEMBL1218971) | ||
Ki | 2.4±n/a nM | ||
Citation | Meng, W; Brigance, RP; Chao, HJ; Fura, A; Harrity, T; Marcinkeviciene, J; O'Connor, SP; Tamura, JK; Xie, D; Zhang, Y; Klei, HE; Kish, K; Weigelt, CA; Turdi, H; Wang, A; Zahler, R; Kirby, MS; Hamann, LG Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J Med Chem53:5620-8 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Dipeptidyl peptidase 8 | |||
Name: | Dipeptidyl peptidase 8 | ||
Synonyms: | DPP8 | DPP8_HUMAN | DPRP-1 | DPRP1 | Dipeptidyl peptidase 8 (DPP-8) | Dipeptidyl peptidase 8 (DPP8) | Dipeptidyl peptidase 8/9 | Dipeptidyl peptidase IV-related protein 1 | Dipeptidyl peptidase VIII | Dipeptidyl peptidase VIII (DDP-VIII) | Prolyl dipeptidase DPP8 | ||
Type: | Enzyme | ||
Mol. Mass.: | 103342.62 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q6V1X1 | ||
Residue: | 898 | ||
Sequence: |
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BDBM50324517 | |||
n/a | |||
Name | BDBM50324517 | ||
Synonyms: | (6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)(morpholino)methanone | CHEMBL1214943 | Sa-(+)-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)(morpholino)methanone | ||
Type | Small organic molecule | ||
Emp. Form. | C19H19Cl2N5O2 | ||
Mol. Mass. | 420.292 | ||
SMILES | Cc1nc2nc(cn2c(c1CN)-c1ccc(Cl)cc1Cl)C(=O)N1CCOCC1 |(3.79,3.47,;2.48,2.65,;1.12,3.37,;-.18,2.56,;-1.66,2.99,;-2.52,1.73,;-1.58,.51,;-.13,1.03,;1.22,.3,;2.53,1.1,;3.89,.38,;5.19,1.19,;1.19,-1.24,;-.16,-1.97,;-.19,-3.51,;1.13,-4.31,;1.1,-5.85,;2.48,-3.56,;2.5,-2.03,;3.85,-1.28,;-4.07,1.68,;-4.87,2.99,;-4.79,.32,;-3.99,-1,;-4.73,-2.35,;-6.27,-2.39,;-7.07,-1.08,;-6.34,.27,)| | ||
Structure |