Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Dipeptidyl peptidase 9 | ||
Ligand | BDBM50324521 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_649274 (CHEMBL1218972) | ||
Ki | 1.9±n/a nM | ||
Citation | Meng, W; Brigance, RP; Chao, HJ; Fura, A; Harrity, T; Marcinkeviciene, J; O'Connor, SP; Tamura, JK; Xie, D; Zhang, Y; Klei, HE; Kish, K; Weigelt, CA; Turdi, H; Wang, A; Zahler, R; Kirby, MS; Hamann, LG Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J Med Chem53:5620-8 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Dipeptidyl peptidase 9 | |||
Name: | Dipeptidyl peptidase 9 | ||
Synonyms: | DPP9 | DPP9_HUMAN | DPRP-2 | DPRP2 | Dipeptidyl peptidase 9 (DDP9) | Dipeptidyl peptidase 9 (DPP-9) | Dipeptidyl peptidase 9 (DPP9) | Dipeptidyl peptidase IV-related protein 2 | Dipeptidyl peptidase IX | Dipeptidyl peptidase IX (DDP-IX) | Dipeptidyl peptidase-like protein 9 | ||
Type: | Enzyme | ||
Mol. Mass.: | 98260.70 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q86TI2 | ||
Residue: | 863 | ||
Sequence: |
| ||
BDBM50324521 | |||
n/a | |||
Name | BDBM50324521 | ||
Synonyms: | 4-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carbonyl)piperazin-2-one | CHEMBL1215016 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H18Cl2N6O2 | ||
Mol. Mass. | 433.291 | ||
SMILES | Cc1nc2nc(cn2c(c1CN)-c1ccc(Cl)cc1Cl)C(=O)N1CCNC(=O)C1 |(7.23,-5.85,;5.92,-6.66,;4.56,-5.95,;3.26,-6.75,;1.79,-6.32,;.92,-7.59,;1.87,-8.81,;3.31,-8.29,;4.66,-9.02,;5.97,-8.21,;7.33,-8.93,;8.64,-8.12,;4.63,-10.55,;3.28,-11.29,;3.25,-12.83,;4.57,-13.63,;4.54,-15.17,;5.92,-12.87,;5.95,-11.34,;7.29,-10.6,;-.62,-7.63,;-1.43,-6.33,;-1.34,-8.99,;-.54,-10.31,;-1.27,-11.66,;-2.81,-11.71,;-3.61,-10.39,;-5.15,-10.43,;-2.88,-9.04,)| | ||
Structure |