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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dipeptidyl peptidase 9 | ||
| Ligand | BDBM50324522 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_649274 (CHEMBL1218972) | ||
| Ki | 1.3±n/a nM | ||
| Citation |  Meng, W; Brigance, RP; Chao, HJ; Fura, A; Harrity, T; Marcinkeviciene, J; O'Connor, SP; Tamura, JK; Xie, D; Zhang, Y; Klei, HE; Kish, K; Weigelt, CA; Turdi, H; Wang, A; Zahler, R; Kirby, MS; Hamann, LG Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J Med Chem53:5620-8 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dipeptidyl peptidase 9 | |||
| Name: | Dipeptidyl peptidase 9 | ||
| Synonyms: | DPP9 | DPP9_HUMAN | DPRP-2 | DPRP2 | Dipeptidyl peptidase 9 (DDP9) | Dipeptidyl peptidase 9 (DPP-9) | Dipeptidyl peptidase 9 (DPP9) | Dipeptidyl peptidase IV-related protein 2 | Dipeptidyl peptidase IX | Dipeptidyl peptidase IX (DDP-IX) | Dipeptidyl peptidase-like protein 9 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 98260.70 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q86TI2 | ||
| Residue: | 863 | ||
| Sequence: |
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| BDBM50324522 | |||
| n/a | |||
| Name | BDBM50324522 | ||
| Synonyms: | (6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)((R)-2-(methoxymethyl)pyrrolidin-1-yl)methanone | CHEMBL1215017 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H23Cl2N5O2 | ||
| Mol. Mass. | 448.346 | ||
| SMILES | COC[C@H]1CCCN1C(=O)c1cn2c(c(CN)c(C)nc2n1)-c1ccc(Cl)cc1Cl |r,wD:3.2,(-4.08,-5.1,;-3.17,-6.34,;-3.8,-7.75,;-2.89,-8.99,;-3.37,-10.45,;-2.12,-11.36,;-.88,-10.45,;-1.34,-8.99,;-.62,-7.63,;-1.43,-6.32,;.92,-7.58,;1.86,-8.8,;3.31,-8.28,;4.66,-9.01,;5.97,-8.21,;7.33,-8.93,;8.63,-8.12,;5.92,-6.66,;7.23,-5.84,;4.56,-5.94,;3.26,-6.75,;1.79,-6.32,;4.63,-10.54,;3.28,-11.28,;3.25,-12.82,;4.57,-13.62,;4.54,-15.16,;5.92,-12.87,;5.94,-11.34,;7.29,-10.59,)| | ||
| Structure | 
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