| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 10 |
|---|
| Ligand | BDBM50324575 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_649559 (CHEMBL1219257) |
|---|
| IC50 | >20000±n/a nM |
|---|
| Citation |  Fang, X; Yin, Y; Chen, YT; Yao, L; Wang, B; Cameron, MD; Lin, L; Khan, S; Ruiz, C; Schröter, T; Grant, W; Weiser, A; Pocas, J; Pachori, A; Schürer, S; Lograsso, P; Feng, Y Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors. J Med Chem53:5727-37 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase 10 |
|---|
| Name: | Mitogen-activated protein kinase 10 |
|---|
| Synonyms: | JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 52586.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 464 |
|---|
| Sequence: | MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
|
|
|
|---|
| BDBM50324575 |
|---|
| n/a |
|---|
| Name | BDBM50324575 |
|---|
| Synonyms: | (R)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)-phenyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxamide | CHEMBL1215171 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H29N5O3 |
|---|
| Mol. Mass. | 435.5188 |
|---|
| SMILES | COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(cc1OCCN(C)C)-c1cn[nH]c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
