| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Steroid 17-alpha-hydroxylase/17,20 lyase |
|---|
| Ligand | BDBM50028166 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_649579 (CHEMBL1219277) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Hu, Q; Jagusch, C; Hille, UE; Haupenthal, J; Hartmann, RW Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer. J Med Chem53:5749-58 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Steroid 17-alpha-hydroxylase/17,20 lyase |
|---|
| Name: | Steroid 17-alpha-hydroxylase/17,20 lyase |
|---|
| Synonyms: | CP17A_HUMAN | CYP17 | CYP17A1 | CYPXVII | Cytochrome P450 17A1 | Cytochrome P450 C17 (CYP17 ) | Cytochrome P450 C17 (CYP17) | Cytochrome P450 CYP17 | Cytochrome P450-C17 | Cytochrome P450-C17 (CYP17) | P450-C17 | S17AH | Steroid 17-alpha-Monooxygenase (CYP17) | Steroid 17-alpha-hydroxylase/17,20 lyase | Steroid 17-alpha-monooxygenase | cytochrome P450 monooxygenase 17 alpha hydroxylase/17,20-lyase (CYP17) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 57382.42 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | E.coli expressing human CYP17 |
|---|
| Residue: | 508 |
|---|
| Sequence: | MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH
WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS
LICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN
DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF
GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV
LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP
AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP
KVVFLIDSFKVKIKVRQAWREAQAEGST
|
|
|
|---|
| BDBM50028166 |
|---|
| n/a |
|---|
| Name | BDBM50028166 |
|---|
| Synonyms: | CHEMBL934 | METYRAPONE | US9138393, Metyrapone | US9144538, Metyrapone | US9394290, MTP (metyrapone) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H14N2O |
|---|
| Mol. Mass. | 226.2738 |
|---|
| SMILES | CC(C)(C(=O)c1cccnc1)c1cccnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
